The manuscript for Lennart’s postdoc project “Transcription establishes microenvironments that organize euchromatin” is now up on bioRxiv.
We investigated how the process of accessing the information contained in DNA leads to its three-dimensional organization. By a combination of STED super-resolution imaging (thank you Alf Honigmann and lab!), Fab-based live imaging (thank you Yuko, and Hiroshi Kimura’s lab!), and physical modeling (thanks Vasily Zaburdaev and lab, and Frank Jülicher!), we concluded that the process is similar to the organization in a microemulsion. With the exception that ours contains not a conventional, but a catalytically active amphiphile.
Oh, and the twitter action’s here…
Our new #preprint "Transcription establishes microenvironments that organize euchromatin" https://t.co/yWzMaB02nh #NuclearArchitecture #GenomeOrganization #SuperRes #ActiveMatter @biorxivpreprint @biorxiv_cellbio @csbdresden @mpicbg @tokyotech_en @cfaed_TUD pic.twitter.com/Tt5wwfyUyR
— Lennart (@LennartHilbert) December 15, 2017