Edlyn Wu, Nadine L Vastenhouw
From mother to embryo: A molecular perspective on zygotic genome activation
Current Topics in Developmental Biology, in press.
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Amanda Amodeo, Johanna Gassler, Ksenia Kuznetsova, Philip Zegerman
Meeting report: 2nd EMBO workshop "Awakening of the genome: the maternal-to-zygotic transition"
The Node. 2020.
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Elliott W. Abrams, Ricardo Fuentes, Florence L. Marlow, Manami Kobayashi, Hong Zhang, Sumei Lu, Lee Kapp, Shai R. Joseph, Amy Kugath, Tripti Gupta, Virginia Lemon, Greg Runke, Amanda A. Amodeo, Nadine L Vastenhouw, Mary C. Mullins
Molecular genetics of maternally-controlled cell divisions
PLoS Genetics. 2020
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Máté Pálfy, Gunnar Schulze, Eivind Valen, Nadine L Vastenhouw
Chromatin accessibility established by Pou5f3, Sox19b, and Nanog primes genes for activity during zebrafish genome activation
PLoS Genetics. 2020
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Yuko Sato, Lennart Hilbert, Haruka Oda, Yinan Wan, John M. Heddleston, Teng-Leong Chew, Vasily Zaburdaev, Philipp Keller, Timothee Lionnet, Nadine Vastenhouw, Hiroshi Kimura
Histone H3K27 acetylation precedes active transcription during zebrafish zygotic genome activation as revealed by live-cell analysis
Development. 2019
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Nadine L Vastenhouw, Wen Xi Cao, Howard D Lipshitz
The maternal-to-zygotic transition revisited
Development. 2019
Free copies available here.


Máté Pálfy
The role of transcription factors in shaping the chromatin landscape and regulating the timing of zygotic genome activation in zebrafish
PhD Thesis, Technische Universität Dresden, defense date: 2018.04.26

Pavel Vopalensky, Sabrina Pralow and Nadine L Vastenhouw
Reduced expression of the Nodal coreceptor Oep causes loss of mesendodermal competence in zebrafish
Development. 2018 Mar 6;145(5)
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Stapel LC, Broaddus C, Vastenhouw NL
Detection and Automated Analysis of Single Transcripts at Subcellular Resolution in Zebrafish Embryos
Methods Mol Biol 1649:143-162 (2018)
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Lennart Hilbert, Yuko Sato, Hiroshi Kimura, Frank Jülicher, Alf Honigmann, Vasily Zaburdaev, and Nadine Vastenhouw
Transcription establishes microenvironments that organize euchromatin
Posted on the bioRxiv on Dec 15 2017, in revision

Kumar M, Joseph SR, Augsburg M, Bogdanova A, Drechsel D, Vastenhouw NL, Buchholz F, Gentzel M, Shevchenko A.
MS Western, a Method of Multiplexed Absolute Protein Quantification is a Practical Alternative to Western Blotting.
Mol Cell Proteomics (2017 Nov 30) [Epub ahead of print]
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Stapel, L Carine; Zechner, Christoph; Vastenhouw, Nadine L
Uniform gene expression in embryos is achieved by temporal averaging of transcription noise.
Genes Dev 31: 1635-1640 (2017)
Article pageRecommended in F1000Prime

Shai Joseph
Competition for DNA binding between histones and transcription factors regulates the timing of zygotic genome activation in zebrafish embryos
PhD Thesis, Technische Universität Dresden, defense date: 2017.10.30

Boothe, Tobias; Hilbert, Lennart; Heide, Michael; Berninger, Lea; Hüttner, Wieland B ; Zaburdaev, Vasily; Vastenhouw, Nadine; Myers, Eugene W; Drechsel, David N; Rink, Jochen C
A tunable refractive index matching medium for live imaging cells, tissues and model organisms.
eLife, 27240 2017
Article PageAlso see Tobias' post on the Node

Joseph, Shai R; Pálfy, Máté; Hilbert, Lennart; Kumar, Mukesh; Karschau, Jens; Zaburdaev, Vasily; Shevchenko, Andrej; Vastenhouw, Nadine L
Competition between histone and transcription factor binding regulates the onset of transcription in zebrafish embryos.
eLife, 23326 (2017)
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Max Krause
The role of Histone H3 Lysine 4 trimethylation in zebrafish embryonic development
PhD Thesis, Technische Universität Dresden, defense date: 2017.03.09

Palfy, Máté; Joseph, Shai R; Vastenhouw, Nadine L
The timing of zygotic genome activation.
Current Opinion in Genetics and Development, 43, pp. 53-60 (2017)
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Stapel, L Carine; Lombardot, Benoit; Broaddus, Coleman; Kainmueller, Dagmar; Jug, Florian; Myers, Eugene W.; Vastenhouw, Nadine
Automated detection and quantification of single RNAs at cellular resolution in zebrafish embryos.
Development, 143, no. 3, pp. 540-546 (2016)
Pubmed EntryAlso see our post on the Node

Carine Stapel
The road to uniform gene expression – How zebrafish embryos overcome a game of chance
PhD Thesis, Technische Universität Dresden, defense date: 2016.09.23


Stapel, L Carine; Vastenhouw, Nadine
Message control in developmental transitions; deciphering chromatin's role using zebrafish genomics.
Brief Funct Genomics, 13, no. 2, pp. 106-120 (2014)
Pubmed Entry

Zhang, Yang; Vastenhouw, Nadine; Feng, Jianxing; Fu, Kai; Wang, Chenfei; Ge, Ying; Hummelen, Paul van; Schier, Alexander F; Liu, Xiaole Shirley
Canonical nucleosome organization at promoters forms during genome activation.
Genome Res, 24, no. 2, pp. 260-266 (2014)
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Vastenhouw, Nadine; Schier, Alexander F
Bivalent histone modifications in early embryogenesis.
Curr Opin Cell Biol, 24, no. 3, pp. 374-386 (2012)
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Pauli, Andrea; Valen, Eivind; Lin, Michael F; Garber, Manuel; Vastenhouw, Nadine; Levin, Joshua Z; Fan, Lin; Sandelin, Albin; Rinn, John L; Regev, Aviv; Schier, Alexander F
Systematic identification of long noncoding RNAs expressed during zebrafish embryogenesis.
Genome Res, 22, no. 3, pp. 577-591 (2012)
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Vastenhouw, Nadine; Zhang, Yang; Woods, Ian G; Imam, Farhad; Regev, Aviv; Liu, X Shirley; Rinn, John L; Schier, Alexander F
Chromatin signature of embryonic pluripotency is established during genome activation.
Nature, 464, no. 7290, pp. 922-926 (2010)
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Vastenhouw, Nadine; Brunschwig, Karin; Okihara, Kristy L; Müller, Fritz; Tijsterman, Marcel; Plasterk, Ronald H A
Gene expression: long-term gene silencing by RNAi.
Nature, 442, no. 7105, pp. 882-882 (2006)
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Haaften, Gijs van; Vastenhouw, Nadine; Nollen, Ellen A A; Plasterk, Ronald H A; Tijsterman, Marcel
Gene interactions in the DNA damage-response pathway identified by genome-wide RNA-interference analysis of synthetic lethality.
Proc Natl Acad Sci U.S.A., 101, no. 35, pp. 12992-12996 (2004)
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Vastenhouw, Nadine; Plasterk, Ronald H A
RNAi protects the Caenorhabditis elegans germline against transposition.
Trends Genet., 20, no. 7, pp. 314-319 (2004)
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Robert, V J P; Vastenhouw, Nadine; Plasterk, Ronald H A
RNA interference, transposon silencing, and cosuppression in the Caenorhabditis elegans germ line: similarities and differences.
Cold Spring Harb Symp Quant Biol, 69, pp. 397-402 (2004)
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Vastenhouw, Nadine; Fischer, Steffi; Robert, V J P; Thijssen, Karen L; Fraser, Andrew G; Kamath, Ravi S; Ahringer, Julie; Plasterk, Ronald H A
A genome-wide screen identifies 27 genes involved in transposon silencing in C. elegans.
Curr Biol, 13, no. 15, pp. 1311-1316 (2003)
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Masselink, H; Vastenhouw, Nadine; Bernards, René
B-myb rescues ras-induced premature senescence, which requires its transactivation domain.
Cancer Lett, 171, no. 1, pp. 87-101 (2001)
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Berkhout, B; Vastenhouw, Nadine; Klasens, B I; Huthoff, H
Structural features in the HIV-1 repeat region facilitate strand transfer during reverse transcription.
RNA, 7, no. 8, pp. 1097-1114 (2001)
Pubmed Entry